16 days in Europe Itinerary

Madrid is known for its cultural and artistic heritage, lively nightlife, and a dynamic culinary scene.

On the 16th (Wed), admire the masterpieces at Royal Palace of Madrid, then see the interesting displays at Prado National Museum, and then see the interesting displays at Museo Nacional Thyssen-Bornemisza.

To see photos, ratings, other places to visit, and more tourist information, use the Madrid online trip itinerary builder .

Sao Paulo, Brazil to Madrid is an approximately 13.5-hour flight. You can also do a combination of bus and flight. The time zone difference when traveling from Sao Paulo to Madrid is 4 hours. Prepare for slightly colder weather when traveling from Sao Paulo in October: high temperatures in Madrid hover around 26°C and lows are around 13°C. Finish up your sightseeing early on the 16th (Wed) so you can catch the train to Barcelona.

Barcelona, the country’s second-largest city, is a cosmopolitan urban center known for its throbbing youthful energy and stellar architecture.

On the 17th (Thu), appreciate the history behind Casa Batllo, tour the pleasant surroundings at Parc Guell, then pause for some serene contemplation at Basilica of the Sagrada Familia, and finally take a stroll through El Barri Gòtic.

To find other places to visit, where to stay, maps, and more tourist information, go to the Barcelona trip itinerary maker app .

You can take a train from Madrid to Barcelona in 3 hours. Other options are to fly; or drive. Traveling from Madrid in October, expect a bit warmer with lows of 18°C in Barcelona. Wrap up your sightseeing on the 17th (Thu) early enough to travel to Paris.

A beautiful and romantic city fit for any itinerary, Paris brims with historic associations and remains vastly influential in the realms of culture, art, fashion, food and design.

Start off your visit on the 18th (Fri): explore the world behind art at Louvre Museum, then explore the world behind art at Musee d'Orsay, and then contemplate the long history of Eiffel Tower.

For ratings, maps, and more tourist information, you can read our Paris trip planner .

You can fly from Barcelona to Paris in 5 hours. Other options are to do a combination of train and flight; or drive. Traveling from Barcelona in October, expect Paris to be slightly colder, temps between 19°C and 10°C. Finish your sightseeing early on the 18th (Fri) so you can take a train to Amsterdam.

Known as one of the greatest small cities in the world, Amsterdam charms visitors with its cool and cozy atmosphere.

On the 19th (Sat), get engrossed in the history at Anne Frank House, then admire the masterpieces at Van Gogh Museum, then admire the masterpieces at Rijksmuseum, and finally explore the world behind art at Museum Het Rembrandthuis (Rembrandt House).

To find reviews, where to stay, photos, and tourist information, read Amsterdam visit planner .

Traveling by train from Paris to Amsterdam takes 3.5 hours. Alternatively, you can fly; or drive. October in Amsterdam sees daily highs of 17°C and lows of 9°C at night. Wrap up your sightseeing on the 19th (Sat) to allow time to travel to Prague.

Prague lures millions of tourists each year with its World Heritage-listed medieval city center--a labyrinth of narrow lanes, bridges, cathedrals, and palaces overlooked by a thousand-year-old castle.

Kick off your visit on the 20th (Sun): take a stroll through Mala strana, then contemplate in the serene atmosphere at St. Vitus Cathedral, then appreciate the extensive heritage of Prague Castle, and finally take a stroll through Old Town Square.

Plan my day in Prague using traveler tips and tourist information provided by Inspirock.

Fly from Amsterdam to Prague in 4.5 hours. Alternatively, you can do a combination of train and flight; or drive. October in Prague sees daily highs of 15°C and lows of 7°C at night. Finish your sightseeing early on the 20th (Sun) to allow enough time to travel to Vienna.

The cultural, economic, and political center of the country, Vienna has developed from its early Celtic and Roman roots into a medieval and Baroque city, with an old town that was designated a World Heritage Site in 2001.

Start off your visit on the 21st (Mon): pause for some serene contemplation at St. Stephen's Cathedral, then see the interesting displays at Kunsthistorisches Museum Wien, then explore the galleries of Belvedere Palace, and finally examine the collection at Imperial Palace (Hofburg).

To find more things to do, other places to visit, traveler tips, and more tourist information, use the Vienna road trip website .

Traveling by flight from Prague to Vienna takes 3 hours. Alternatively, you can drive; or take a bus. In October, plan for daily highs up to 17°C, and evening lows to 8°C. Cap off your sightseeing on the 21st (Mon) early enough to travel to Istanbul.

A physical and cultural bridge between Europe and Asia, the transcontinental city of Istanbul serves as a living reminder of the Roman, Byzantine, and Ottoman empires.

On the 22nd (Tue), admire the masterpieces at Kariye Museum (The Chora Church), get engrossed in the history at Topkapi Palace, get engrossed in the history at Hagia Sophia Museum / Church (Ayasofya), then take in the spiritual surroundings of Sultan Ahmed Mosque, and finally admire the masterpieces at Istanbul Modern Museum.

To see photos, where to stay, ratings, and more tourist information, read Istanbul road trip website .

You can fly from Vienna to Istanbul in 5.5 hours. Alternatively, you can do a combination of flight and shuttle; or drive. Due to the time zone difference, you'll lose 2 hours traveling from Vienna to Istanbul. When traveling from Vienna in October, plan for a bit warmer days and much hotter nights in Istanbul: temperatures range from 28°C by day to 26°C at night. Finish up your sightseeing early on the 22nd (Tue) so you can travel to Venice.

Virtually unchanged for the last six centuries, Venice is actually a group of islands made famous by a series of canals, bridges, monuments, piazzas, and narrow pedestrian lanes.

On the 23rd (Wed), see the interesting displays at Museo Ebraico di Venezia, contemplate the waterfront views at Canal Grande, don't miss a visit to Basilica di San Marco, get to know the fascinating history of St. Mark's Square, then take in the views from Ponte dei Sospiri, and finally browse the exhibits of Doge's Palace.

To find other places to visit, photos, more things to do, and tourist information, go to the Venice trip builder website .

You can fly from Istanbul to Venice in 5.5 hours. Alternatively, you can do a combination of flight and train; or drive. Traveling from Istanbul to Venice, you'll gain 2 hours due to the time zone difference. Expect little chillier weather when traveling from Istanbul in October: highs in Venice hover around 22°C, while lows dip to 12°C. Cap off your sightseeing on the 23rd (Wed) early enough to catch the train to Florence.

Considered a cultural, artistic, and architectural jewel of Italy, Florence is the birthplace of the Italian Renaissance.

On the 24th (Thu), take in panoramic vistas at Campanile di Giotto, take in the architecture and atmosphere at Cathedral of Santa Maria del Fiore, admire the masterpieces at Pitti Palace, then admire the masterpieces at Uffizi Galleries, and finally steep yourself in history at The Baptistery of St. John. Here are some ideas for day two: see the interesting displays at Academy Of Florence Art Gallery, see the interesting displays at Museo di San Marco, snap pictures at Ponte Vecchio, get great views at Piazzale Michelangelo, then take an in-depth tour of Basilica di Santa Croce, and finally get to know the fascinating history of Piazza del Duomo.

To see where to stay, other places to visit, traveler tips, and more tourist information, go to the Florence journey tool .

Getting from Venice to Florence by train takes about 2.5 hours. Other options: drive; or take a bus. In October, daytime highs in Florence are 25°C, while nighttime lows are 14°C. Finish up your sightseeing early on the 25th (Fri) so you can catch the train to Rome.

Aptly nicknamed the Eternal City, Rome is the birthplace of the Roman Empire, one of the world's greatest civilizations ever.

Get outdoors at Catacombe di San Callisto and Passeggiata di Gianicolo. Get some cultural insight at Vatican Museums and St. Peter's Basilica. The adventure continues: make a trip to Pantheon, wander the streets of Trastevere, admire the local landmark of Trevi Fountain, and explore the world behind art at Musei Capitolini.

To find other places to visit, more things to do, ratings, and more tourist information, go to the Rome sightseeing planning website .

Traveling by train from Florence to Rome takes 2 hours. Alternatively, you can drive; or fly. Expect a daytime high around 26°C in October, and nighttime lows around 15°C. Wrap up your sightseeing by early afternoon on the 30th (Wed) to allow enough time to travel back home.