16 days in South America Itinerary

16 days in South America Itinerary

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Route & dates

16 days in South America Itinerary

Start: Guadalajara, Mexico
Fly:  13 h 45 min
1
Cusco, Peru
— 2 nights
Fly + Shuttle:  8 h 15 min
2
San Pedro de Atacama, Chile
— 1 night
Shuttle + Fly:  5 h
3
Santiago, Chile
— 1 night
Fly:  4 h 45 min
4
Buenos Aires, Argentina
— 3 nights
Fly:  7 h
5
Rio de Janeiro, Brazil
— 2 nights
Fly + Bus:  1 h 30 min
6
Sao Paulo, Brazil
— 4 nights
Fly:  13 h 45 min
End: Guadalajara, Mexico

2
nights
Cusco, Peru

Cusco ©
Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
Visit Sacsayhuaman and Iglesia De Santo Domingo for their historical value. Explore hidden gems such as Sacred Valley of the Incas and Q'enqo. There's lots more to do: contemplate the long history of Plaza de Armas, surround yourself with nature on a nature and wildlife tour, and make a trip to San Blas.

To find other places to visit, topicsMoreInfo.option.ratings, where to stay, and more tourist information, you can read our Cusco online tour planner .

Guadalajara, Mexico to Cusco is an approximately 14-hour flight. You can also do a combination of bus and flight. The time zone difference when traveling from Guadalajara to Cusco is 1 hour. When traveling from Guadalajara in March, plan for slightly colder days in Cusco, with highs around 23°C, while nights are about the same with lows around 9°C. Wrap up your sightseeing on the 29th (Mon) early enough to travel to San Pedro de Atacama.

Things to do in Cusco

Historic Sites Tours Outdoors

Side Trip

Sacred Valley of the Incas
Find places to stay Mar 26 — 29:
Highlights from your plan
Sacsayhuaman ©
Sacsayhuaman
Sacred Valley of the Incas ©
Sacred Valley of the Incas
Q'enqo ©
Q'enqo

1
night
San Pedro de Atacama, Chile

San Pedro de Atacama ©
Major archeological sites and a renowned museum remain the big draws in San Pedro de Atacama tourism, appealing to visitors interested in learning more about South America's pre-Columbian cultures.
Start off your visit on the 30th (Tue): get curious at Museo del Meteorito, make a trip to Mirador de Kari, Piedra del Coyote, and then contemplate the waterfront views at Tebinquinche Lake. On the next day, delve into the distant past at Pukara de Quitor and then contemplate the waterfront views at Lagunas Miscanti y Miniques.

To see photos, traveler tips, topicsMoreInfo.option.ratings, and more tourist information, use the San Pedro de Atacama itinerary site .

You can do a combination of flight and shuttle from Cusco to San Pedro de Atacama in 8.5 hours. Alternatively, you can drive; or take a bus. Due to the time zone difference, you'll lose 1 hour traveling from Cusco to San Pedro de Atacama. Traveling from Cusco in March, expect nights in San Pedro de Atacama to be about the same, around 7°C, while days are a bit warmer, around 28°C. Wrap up your sightseeing on the 31st (Wed) to allow time to travel to Santiago.

Things to do in San Pedro de Atacama

Parks Nature Historic Sites
Find places to stay Mar 29 — 31:
Highlights from your plan
Lagunas Miscanti y Miniques ©
Lagunas Miscanti y Miniques
Pukara de Quitor ©
Pukara de Quitor
Museo del Meteorito ©
Museo del Meteorito

1
night
Santiago, Chile

Santiago ©
Santiago tourism thrives largely thanks to the city's big selection of cultural and entertainment options, including museums, theaters, restaurants, bars, and giant malls.
On the 1st (Thu), explore the world behind art at Museo Chileno de Arte Precolombino, then examine the collection at La Chascona, and then walk around Cerro Santa Lucia.

To see more things to do, topicsMoreInfo.option.ratings, and more tourist information, refer to the Santiago vacation planning site .

Traveling by combination of shuttle and flight from San Pedro de Atacama to Santiago takes 5 hours. Alternatively, you can drive; or take a bus. Finish up your sightseeing early on the 1st (Thu) so you can travel to Buenos Aires.

Things to do in Santiago

Museums Parks
Find places to stay Mar 31 — Apr 1:
Highlights from your plan
La Chascona ©
La Chascona
Museo Chileno de Arte Precolombino ©
Museo Chileno de Arte Precolombino
Cerro Santa Lucia ©
Cerro Santa Lucia

3
nights
Buenos Aires, Argentina

Buenos Aires ©
Cultural capital of South America, Buenos Aires remains one of the largest cities on the continent, serving as a point of departure for exploring the rest of the country.
You'll discover tucked-away gems like Museo Nacional de Bellas Artes and Palacio Barolo. Cemiterio de Recoleta and La Boca are good opportunities to explore the local culture. The adventure continues: take a stroll through Puerto Madero, get a sense of history and politics at Casa Rosada, admire the natural beauty at Parque 3 de Febrero, and take in the architecture and atmosphere at Catedral Primada.

To find more things to do, reviews, photos, and more tourist information, refer to the Buenos Aires day trip tool .

You can fly from Santiago to Buenos Aires in 5 hours. Alternatively, you can drive; or take a bus. The time zone difference when traveling from Santiago to Buenos Aires is 1 hour. In April, plan for daily highs up to 26°C, and evening lows to 19°C. Finish up your sightseeing early on the 4th (Sun) so you can travel to Rio de Janeiro.

Things to do in Buenos Aires

Historic Sites Neighborhoods Museums
Find places to stay Apr 1 — 4:
Highlights from your plan
Cemiterio de Recoleta ©
Cemiterio de Recoleta
Puerto Madero ©
Puerto Madero
Museo Nacional de Bellas Artes ©
Museo Nacional de Bellas Artes

2
nights
Rio de Janeiro, Brazil

Rio de Janeiro
Bustling with samba music and all-night street parties, no city encapsulates the spirit of Brazil better than Rio de Janeiro.
Start off your visit on the 5th (Mon): pause for some photo ops at Corcovado - Christ the Redeemer, admire the natural beauty at Jardim Botânico do Rio de Janeiro, then enjoy the sand and surf at Praia de Ipanema, and finally kick back and relax at Pedra do Arpoador. On the 6th (Tue), you'll have a packed day of sightseeing: engage your brain at Museu do Amanha, enjoy the sand and surf at Copacabana Beach, then take some stellar pictures from Leblon Beach, and finally steep yourself in history at Parque Lage.

For other places to visit, traveler tips, maps, and tourist information, read our Rio de Janeiro trip maker app .

You can fly from Buenos Aires to Rio de Janeiro in 7 hours. Alternatively, you can drive; or take a bus. In April, Rio de Janeiro is a bit warmer than Buenos Aires - with highs of 33°C and lows of 26°C. Finish up your sightseeing early on the 6th (Tue) so you can travel to Sao Paulo.

Things to do in Rio de Janeiro

Parks Beaches Outdoors
Find places to stay Apr 4 — 6:
Highlights from your plan
Praia de Ipanema
Praia de Ipanema
Copacabana Beach ©
Copacabana Beach
Parque Lage ©
Parque Lage

4
nights
Sao Paulo, Brazil

Sao Paulo ©
Don't let the city's nickname--"Land of Drizzle"--dampen your spirits during a trip to Sao Paulo.
Your cultural itinerary includes sights like Matriz Basilica Nossa Senhora Aparecida and Museu do Futebol. Relax by the water at Juquehy Beach and Tombo Beach. Go for a jaunt from Sao Paulo to Aparecida to see National Sanctuary of Our Lady of Aparecida about 1h 55 min away. The adventure continues: admire the masterpieces at Pinacoteca do Estado de Sao Paulo.

For where to stay, reviews, photos, and other tourist information, you can read our Sao Paulo road trip planning app .

You can do a combination of flight and bus from Rio de Janeiro to Sao Paulo in 1.5 hours. Alternatively, you can fly; or drive. Traveling from Rio de Janeiro in April, expect Sao Paulo to be slightly colder, temps between 30°C and 20°C. On the 10th (Sat), you're off to home.

Things to do in Sao Paulo

Beaches Parks Outdoors

Side Trips

Aparecida, Tombo Beach, Juquehy Beach
Find places to stay Apr 6 — 10:
Highlights from your plan
Juquehy Beach ©
Juquehy Beach
Tombo Beach ©
Tombo Beach

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