21 days in Argentina, Chile & Peru Itinerary

21 days in Argentina, Chile & Peru Itinerary

Created using Inspirock South America trip itinerary builder

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Fly
1
Buenos Aires, Argentina
— 3 nights
Fly
2
Mendoza, Argentina
— 3 nights
Fly
3
Santiago, Chile
— 3 nights
Drive
4
Valparaiso, Chile
— 4 nights
Fly
5
Cusco, Peru
— 4 nights
Bus to Ollantaytambo, Train to Machu Picchu
6
Machu Picchu, Peru
— 1 night
Fly

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Buenos Aires, Argentina

— 3 nights

Queen of La Plata

Cultural capital of South America, Buenos Aires remains one of the largest cities on the continent, serving as a point of departure for exploring the rest of the country.
Do some cultural sightseeing at Puerto Madero and Cemiterio de Recoleta. Museum-lovers will appreciate Museo Nacional de Bellas Artes and Museo de los Ninos. There's lots more to do: explore the world behind art at Museo de Arte Latinoamericano de Buenos Aires, wander the streets of Recoleta, ponder the world of politics at Casa Rosada, and take in nature's colorful creations at Parque 3 de Febrero.

To see other places to visit, ratings, maps, and tourist information, go to the Buenos Aires tour planning app.

Sao Paulo, Brazil to Buenos Aires is an approximately 6.5-hour flight. You can also drive; or do a combination of bus and ferry. Prepare for a bit cooler weather when traveling from Sao Paulo in May: high temperatures in Buenos Aires hover around 20°C and lows are around 14°C. Finish your sightseeing early on the 14th (Fri) so you can travel to Mendoza.

Things to do in Buenos Aires

Museums · Historic Sites · Neighborhoods · Shopping
Find places to stay May 10 — 14:

Mendoza, Argentina

— 3 nights
Famed for its neat vineyards and thriving wine production, Mendoza remains the place to visit for a pleasant combination of relaxation and recreation.
Your cultural itinerary includes sights like Bodega Cruzat. Bubbles Experience and Catena Zapata. Change things up with these side-trips from Mendoza: Casa El Enemigo (in Maipu) and Valle de Uco (in Tupungato). Next up on the itinerary: learn about winemaking at Bodega Tierras Altas, sample the fine beverages at Casa Tapaus Destilados, get engrossed in the history at Museo Fundacional, and stroll around Parque General San Martin.

To see other places to visit and more tourist information, read our Mendoza trip planner.

Traveling by flight from Buenos Aires to Mendoza takes 4 hours. Alternatively, you can drive; or take a bus. Traveling from Buenos Aires in May, expect a bit cooler with lows of 9°C in Mendoza. Wrap up your sightseeing on the 17th (Mon) to allow time to travel to Santiago.

Things to do in Mendoza

Wineries · Parks · Museums · Nature

Side Trips

Find places to stay May 14 — 17:

Santiago, Chile

— 3 nights

City of the Island Hills

Santiago tourism thrives largely thanks to the city's big selection of cultural and entertainment options, including museums, theaters, restaurants, bars, and giant malls.
Satisfy your inner culture vulture at Museo Chileno de Arte Precolombino and Centro Cultural Palacio de la Moneda y Plaza de la Ciudadania. Let the collections at La Chascona and National Museum of Natural History capture your imagination. Next up on the itinerary: take in the awesome beauty at San Cristóbal Hill, get engrossed in the history at Museo de la Memoria y los Derechos Humanos, take a stroll through Barrio Bellavista, and explore the world behind art at Chilean National Museum of Fine Arts.

To see traveler tips, ratings, where to stay, and more tourist information, go to the Santiago route builder.

Traveling by flight from Mendoza to Santiago takes 4.5 hours. Alternatively, you can drive; or take a bus. The time zone difference when traveling from Mendoza to Santiago is minus 1 hour. Wrap up your sightseeing on the 20th (Thu) to allow time to drive to Valparaiso.

Things to do in Santiago

Museums · Neighborhoods · Parks · Nature
Find places to stay May 17 — 20:

Valparaiso, Chile

— 4 nights

Jewel of the Pacific

Navigating through a maze of colorful streets winding up and down steep hills remains an integral part of any Valparaiso tour.
Get some cultural insight at Casa de Isla Negra and Edificio Luis Cousino. Take a break from the city and head to Playa de Zapallar and Reñaca. You'll find plenty of places to visit near Valparaiso: La Rambla (in Zapallar), Playa El Pejerrey (in Algarrobo) and Matetic Vineyards (in Lagunillas). There's still lots to do: see the interesting displays at La Sebastiana and enjoy the sand and surf at Rocas de Santo Domingo.

For traveler tips, where to stay, and other tourist information, refer to the Valparaiso attractions planning app.

Traveling by car from Santiago to Valparaiso takes 1.5 hours. Alternatively, you can take a bus. In May, daytime highs in Valparaiso are 19°C, while nighttime lows are 11°C. Finish up your sightseeing early on the 24th (Mon) so you can travel to Cusco.

Things to do in Valparaiso

Parks · Outdoors · Beaches · Museums

Side Trips

Find places to stay May 20 — 24:

Cusco, Peru

— 4 nights

Imperial City

Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
Sacsayhuaman and San Blas are good opportunities to explore the local culture. Take a break from the city and head to Salinas de Maras and exploor. Step out of Cusco with an excursion to Moray in Maras--about 1h 20 min away. The adventure continues: explore the world behind art at Museo de Arte Precolombino, delve into the distant past at Centro Historico De Cusco, take in the spiritual surroundings of Museo de Vida Monastica - Monasterio de Santa Catalina del Cusco, and pause for some serene contemplation at Cusco Cathedral.

To find more things to do, other places to visit, traveler tips, and tourist information, read our Cusco journey site.

You can fly from Valparaiso to Cusco in 7.5 hours. Alternatively, you can drive; or take a bus. The time zone difference moving from Chile Standard Time to Peru Standard Time is minus 1 hour. Expect somewhat warmer weather when traveling from Valparaiso in May: highs in Cusco hover around 24°C, while lows dip to 4°C. Wrap up your sightseeing on the 28th (Fri) early enough to travel to Machu Picchu.

Things to do in Cusco

Historic Sites · Museums · Parks · Neighborhoods

Side Trip

Find places to stay May 24 — 28:

Machu Picchu, Peru

— 1 night
A symbol of the Incan civilization, the abandoned city of Machu Picchu represents a must-see on a Peru vacation.
Start off your visit on the 29th (Sat): steep yourself in history at Santuario Historico de Machu Picchu, then pause for some serene contemplation at Iglesia Virgen Del Carmen, and then look for gifts at Mapi Art.

To plan Machu Picchu vacation without wasting time, ask Inspirock to design an itinerary.

Getting from Cusco to Machu Picchu by combination of bus and train takes about 4 hours. Other options: take a train; or drive. Finish up your sightseeing early on the 29th (Sat) so you can travel back home.

Things to do in Machu Picchu

Historic Sites · Shopping
Find places to stay May 28 — 29:

Argentina travel guide

4.4
Landmarks · Specialty Museums · Bodies of Water
Land of Contrasts
Home to the highest and lowest points in South America, diverse Argentina enthralls visitors with its contrasting landscapes and rich cultural heritage. A tour of Argentina reveals a sprawling land of fiercely proud and hardworking gauchos, the legendary cowboys of South America's pampas. A vacation in Argentina also leads you to giant urban centers, filled with modern tourist attractions that include fine restaurants, award-winning museums, and renowned public parks, gardens, and zoos. Away from big cities, Argentina sightseeing combines visits to mighty waterfalls situated inside World Heritage-listed national parks in the north of the country, with excursions to icy glaciers in the south.

Chile travel guide

4.3
Landmarks · Parks · Specialty Museums
Land of Poets
Squeezed between the Andes and the Pacific Ocean, geographically diverse Chile is a long, thin stretch of land encompassing some of the world's driest deserts in the north, and some of its largest glacial fields in the south. Though most Chile holidays include some form of adventure in the vast wilderness areas, the country also contains charming cities providing plenty of urban things to do and see. Many tours of Chile include at least a brief visit to the country's lush wine regions, where backyard vineyards compete with sprawling estates producing some of the world's most respected whites and reds.

Peru travel guide

4.6
Historic Sites · Parks · Landmarks
Land of the Incas
In a country renowned for its pre-Columbian archeological sites, no Peru vacation would be complete without an adrenaline-inducing hike to Machu Picchu, World Heritage-listed symbol of the once-mighty Incan Empire. Aside from visiting these spectacular ruins set against the backdrop of photogenic mountain peaks, most holidays in Peru also include an exploration of the country's pretty cities, boasting well-preserved colonial architecture and a slew of modern buildings housing fine museums, galleries, shops, and restaurants. Ideal for active vacationers, Peru trips are also tailor-made for gourmands, as the country's eclectic cuisine blends tasty influences from Africa, Asia, and Europe.