21 days in South America & Europe Itinerary

Colombia's heart and soul, Bogota has earned the nickname "Athens of South America" thanks to its abundance of universities, libraries, and lower-level schools.

Kick off your visit on the 2nd (Thu): soothe aching muscles at some of the top local wellness centers, see the interesting displays at Gold Museum (Museo del Oro), and then admire the masterpieces at Museo Botero del Banco de la Republica. On the next day, take in the awesome beauty at Monserrate, then let your taste buds guide you at a local gastronomic tour, and then stop by Vitrina Guayca.

To see other places to visit, traveler tips, and other tourist information, you can read our Bogota tour itinerary planner.

If you are flying in from Colombia, the closest major aiport is El Dorado International Airport. In September, daily temperatures in Bogota can reach 22°C, while at night they dip to 9°C. Finish your sightseeing early on the 4th (Sat) so you can travel to Madrid.

Madrid is known for its cultural and artistic heritage, lively nightlife, and a dynamic culinary scene.

Venture out of the city with trips to Toledo (MQM Museo del Queso Manchego Toledo & Catedral Primada). There's lots more to do: admire the masterpieces at Prado National Museum, make a trip to Puerta del Sol, stroll around Parque del Retiro, and steep yourself in history at Plaza Mayor.

To find ratings, other places to visit, and other tourist information, refer to the Madrid holiday site.

Getting from Bogota to Madrid by flight takes about 14 hours. Due to the time zone difference, you'll lose 6 hours traveling from Bogota to Madrid. Traveling from Bogota in September, expect Madrid to be somewhat warmer, temps between 32°C and 17°C. Wrap up your sightseeing on the 7th (Tue) to allow time to travel to Berlin.

The country's capital and largest city, Berlin is a diverse urban center boasting a lively nightlife and countless things to do.

Berlin is known for museums, historic sites, and nightlife. Your plan includes some of its best attractions: pause for some photo ops at The Holocaust Memorial - Memorial to the Murdered Jews of Europe, take in the local highlights with Walking tours, steep yourself in history at East Side Gallery, and ponder the world of politics at Reichstag Building.

For traveler tips, more things to do, photos, and other tourist information, refer to the Berlin trip maker website.

Getting from Madrid to Berlin by flight takes about 6.5 hours. Other options: take a train; or drive. You will have some time to spend on the 11th (Sat) before leaving for Brussels.

The allure of the multi-cultural capital, Brussels, stems from its mix of political intrigue, artistic influence, historical significance, and a thriving social scene.

Explore Brussels' surroundings by going to Bruges ('t Apostelientje, Belfry of Bruges, &more). And it doesn't end there: steep yourself in history at Grand Place, explore the world behind art at Musées Royaux des Beaux-Arts de Belgique, admire the striking features of St. Michael and St. Gudula Cathedral (Cathedrale St-Michel et Ste-Gudule), and browse the exhibits of Atomium.

Use Inspirock's suggestions to plan your Brussels trip and find the best activities and attractions for your vacation.

Fly from Berlin to Brussels in 4.5 hours. Alternatively, you can take a train; or drive. In September, plan for daily highs up to 21°C, and evening lows to 11°C. Finish your sightseeing early on the 15th (Wed) to allow enough time to travel to Prague.

Prague lures millions of tourists each year with its World Heritage-listed medieval city center--a labyrinth of narrow lanes, bridges, cathedrals, and palaces overlooked by a thousand-year-old castle.

Prague is known for historic sites, nightlife, and museums. Your plan includes some of its best attractions: take in the views from Charles Bridge, take a stroll through Lesser Town, tour the pleasant surroundings at The Vrtba Garden, and take an in-depth tour of Jewish Museum in Prague.

For other places to visit, reviews, more things to do, and more tourist information, read our Prague road trip tool.

Getting from Brussels to Prague by flight takes about 5 hours. Other options: drive; or take a train. In September, daily temperatures in Prague can reach 22°C, while at night they dip to 12°C. Wrap up your sightseeing on the 18th (Sat) early enough to travel to Paris.

A beautiful and romantic city fit for any itinerary, Paris brims with historic associations and remains vastly influential in the realms of culture, art, fashion, food and design.

Take a break from Paris with a short trip to Palace of Versailles in Versailles, about 48 minutes away. And it doesn't end there: admire the striking features of Louvre Museum, admire all the interesting features of Eiffel Tower, explore the world behind art at Musee d'Orsay, and shop like a local with Le Marais.

For photos, traveler tips, reviews, and tourist information, read our Paris trip planner.

Getting from Prague to Paris by flight takes about 5.5 hours. Other options: drive; or take a train. Expect a daytime high around 24°C in September, and nighttime lows around 13°C. Wrap up your sightseeing on the 22nd (Wed) to allow time to travel back home.