60 days in South America, Central America & Mexico Itinerary

60 days in South America, Central America & Mexico Itinerary

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Route & dates

60 days in South America, Central America & Mexico Itinerary

Start: Cuiaba, Brazil
Fly:  15​h
1
Cartagena, Colombia
— 4 nights
+3
Fly + shuttle + foot + bus:  11​h 30​min
2
Manuel Antonio, Costa Rica
— 2 nights
Drive:  4​h 15​min
3
La Fortuna de San Carlos, Costa Rica
— 5 nights
4
Tamarindo, Costa Rica
— 5 nights
+2
shuttle + bus + Fly:  9​h 15​min
5
Roatan, Honduras
— 4 nights
Fly + Drive:  6​h
6
Cayo, Belize
— 3 nights
Drive + Fly:  7​h 15​min
7
Mexico City, Mexico
— 4 nights
8
San Miguel de Allende, Mexico
— 5 nights
Drive:  4​h 30​min
9
Puebla, Mexico
— 5 nights
+2
Fly + shuttle + bus:  7​h
10
Chichen Itza, Mexico
— 1 night
11
Tulum, Mexico
— 5 nights
+2
bus + foot + Fly:  7​h
12
Panama City, Panama
— 3 nights
taxi + Fly:  2​h 15​min
13
Bogota, Colombia
— 5 nights
Drive:  12​h
End: Cuiaba, Brazil

4
nights
Cartagena, Colombia

Cartagena ©
The site of the continent's first Spanish colony, Cartagena retains much of its colonial flavor thanks to a World Heritage-listed old town, encircled by old walls and protected by imposing fortresses.
Visit Walled City of Cartagena and San Felipe de Barajas Castle for their historical value. Plaza Santo Domingo and Convent of Santa Cruz de la Popa are good opportunities to explore the local culture. Take a break from Cartagena with a short trip to Playa Blanca in Isla Baru, about 1h 05 min away. And it doesn't end there: choose your vessel at Boats4U, don't miss a visit to Plaza de La Trinidad, contemplate the long history of Torre del Reloj, and hit the best photo ops around with an inspiring photography tour.

To see ratings, where to stay, other places to visit, and tourist information, read Cartagena road trip planner.

Cuiaba, Brazil to Cartagena is an approximately 15-hour flight. You can also do a combination of flight and bus; or drive. Due to the time zone difference, you'll gain 1 hour traveling from Cuiaba to Cartagena. Traveling from Cuiaba in August, Cartagena is a bit warmer at night with lows of 30°C. Finish up your sightseeing early on the 6th (Tue) so you can travel to Manuel Antonio.

Things to do in Cartagena

Historic Sites Neighborhoods Outdoors

Side Trip

Playa Blanca
Find places to stay Aug 2 — 6:
Highlights from your plan
Walled City of Cartagena ©
Walled City of Cartagena
Castillo San Felipe de Barajas ©
Castillo San Felipe de Barajas
Plaza Santo Domingo ©
Plaza Santo Domingo

2
nights
Manuel Antonio, Costa Rica

Manuel Antonio ©
The rainforest meets the sea at Manuel Antonio National Park, a small but scenic natural preserve on the west coast of Costa Rica.
Relax by the water at Playa Manuel Antonio and Playa Espadilla Norte. Make the 9th (Fri) an awe-inspiring day at Naturalist Michael Araya Flores. There's still lots to do: get interesting insight from Tours, stop by Meli Melo Boutique, and kick back and relax at Playa Biesanz.

To see other places to visit, photos, reviews, and more tourist information, go to the Manuel Antonio online trip builder .

Traveling by combination of flight and bus from Cartagena to Manuel Antonio takes 11.5 hours. Alternatively, you can do a combination of flight, car, bus, and taxi. You'll gain 1 hour traveling from Cartagena to Manuel Antonio due to the time zone difference. Wrap up your sightseeing on the 9th (Fri) to allow time to drive to La Fortuna de San Carlos.

Things to do in Manuel Antonio

Parks Outdoors Beaches

Side Trip

Quepos
Find places to stay Aug 6 — 9:
Highlights from your plan
Playa Manuel Antonio ©
Playa Manuel Antonio
Playa Biesanz ©
Playa Biesanz
Playa Espadilla Norte ©
Playa Espadilla Norte

5
nights
La Fortuna de San Carlos, Costa Rica

La Fortuna de San Carlos ©
Set against the backdrop of the imposing Arenal Volcano, La Fortuna de San Carlos offers visitors a chance to explore diverse natural landscapes and sample some delicious local produce.
Onirica Art Gallery and Coco Loco Art Studio & Gallery will appeal to museum buffs. Your cultural itinerary includes sights like Iglesia de La Fortuna de San Carlos and Galeria Estudio. There's much more to do: relax and float downstream with a rafting and tubing tour, soothe aching muscles at Tabacon Hot Springs, witness a stunning natural landmark at Eco Termales Hot Springs, and take in the dramatic scenery at La Fortuna Waterfall.

To find where to stay, ratings, traveler tips, and tourist information, you can read our La Fortuna de San Carlos trip itinerary app .

Traveling by car from Manuel Antonio to La Fortuna de San Carlos takes 4.5 hours. Alternatively, you can take a shuttle; or take a bus. Finish up your sightseeing early on the 14th (Wed) so you can go by car to Tamarindo.

Things to do in La Fortuna de San Carlos

Parks Nature Outdoors

Side Trip

Arenal Volcano National Park
Find places to stay Aug 9 — 14:
Highlights from your plan
Tabacon Hot Springs ©
Tabacon Hot Springs
Arenal Volcano (Volcan Arenal)
Arenal Volcano (Volcan Arenal)
River Rafting & Tubing

5
nights
Tamarindo, Costa Rica

Tamarindo ©
Surfing remains the main reason to take a trip to Tamarindo, as the beachside town is mostly known for its excellent waves.
You'll get in some beach time at Playa Conchal and Samara Beach. Get out of town with these interesting Tamarindo side-trips: Playa Buena Vista (in Playa Samara), Playa Nacascolo (in Gulf of Papagayo) and Nosara (Nosara Beach (Playa Guiones) & MAEL's ABSTRACT ART GALLERY). Next up on the itinerary: enjoy the sand and surf at Tamarindo Beach, stroll through Playa Hermosa, and explore and take pictures at Pura Aventura.

To find other places to visit, traveler tips, photos, and more tourist information, go to the Tamarindo journey planner.

Drive from La Fortuna de San Carlos to Tamarindo in 4 hours. Alternatively, you can take a shuttle; or take a bus. Wrap up your sightseeing on the 19th (Mon) to allow time to travel to Roatan.

Things to do in Tamarindo

Beaches Outdoors Parks

Side Trips

Nosara, Playa Samara, Playa Ocotal, Playa Hermosa, Playa Conchal
Find places to stay Aug 14 — 19:
Highlights from your plan
Playa Conchal ©
Playa Conchal
Samara Beach ©
Samara Beach
Nosara Beach (Playa Guiones) ©
Nosara Beach (Playa Guiones)

4
nights
Roatan, Honduras

Roatan ©
The largest of the Bay Islands, Roatan is the most developed and the most popular among its neighbors.
Museum-lovers will get to explore Roatan Underwater Museum and Shawn Jackson Gallery. We've included these beaches for you: West Bay Beach and Sandy Bay. Next up on the itinerary: tour the pleasant surroundings at Tabyana Beach, whizz through the canopy at some of the top local zipline courses and adventure parks, look for gifts at Pies Bonitos, and cool off at Grand Roatan Beach Club.

To see traveler tips, more things to do, and other tourist information, read Roatan journey planning app .

Getting from Tamarindo to Roatan by combination of shuttle and flight takes about 9.5 hours. In August, plan for daily highs up to 38°C, and evening lows to 28°C. Finish up your sightseeing early on the 24th (Sat) so you can travel to Cayo.

Things to do in Roatan

Outdoors Parks Beaches
Find places to stay Aug 19 — 24:
Highlights from your plan
West Bay Beach ©
West Bay Beach
Tabyana Beach ©
Tabyana Beach
Roatan Underwater Museum ©
Roatan Underwater Museum

3
nights
Cayo, Belize

Cayo ©
Holidays in Cayo offer adventure and history in equal measure, with a wealth of ancient sites and unspoiled environment to explore.
Xunantunich and Caracol will appeal to history buffs. Your cultural itinerary includes sights like Tanah Mayan Art Museum and Chaa Creek Natural History Museum. You'll find plenty of places to visit near Cayo: Half Moon Caye National Monument (in Glovers Reef Atoll) and The Belize Zoo (in La Democracia). There's much more to do: Head underground at Actun Tunichil Muknal, don't miss a visit to House of Culture, and take in the dramatic scenery at Rio On Pools.

To see where to stay and more tourist information, refer to the Cayo day trip site .

You can do a combination of flight and shuttle from Roatan to Cayo in 6 hours. Alternatively, you can do a combination of flight and car. In August, daytime highs in Cayo are 37°C, while nighttime lows are 30°C. Finish your sightseeing early on the 28th (Wed) so you can travel to Mexico City.

Things to do in Cayo

Parks Nature Historic Sites

Side Trips

Half Moon Caye National Monument, The Belize Zoo
Find places to stay Aug 24 — 28:
Highlights from your plan
The Belize Zoo ©
The Belize Zoo
Caracol ©
Caracol
Rio On Pools ©
Rio On Pools

4
nights
Mexico City, Mexico

Mexico City ©
Breathtakingly large, Mexico City provides a home for almost 9 million people living in nearly 1,700 distinct neighborhoods.
Do some cultural sightseeing at National Museum of Anthropology and Museo del Templo Mayor. Visit Zona Arqueologica Teotihuacan and National Palace (Palacio Nacional) for their historical value. And it doesn't end there: explore the world behind art at Palacio de Bellas Artes, get engrossed in the history at Museo Casa Luis Barragan, explore the ancient world of Metropolitan Cathedral (Catedral Metropolitana), and see the interesting displays at Frida Kahlo Museum.

To find more things to do, ratings, photos, and more tourist information, read Mexico City itinerary builder tool .

Traveling by combination of car and flight from Cayo to Mexico City takes 7.5 hours. Alternatively, you can do a combination of shuttle and flight; or drive. Expect little chillier weather when traveling from Cayo in August: highs in Mexico City hover around 28°C, while lows dip to 16°C. Finish up your sightseeing early on the 2nd (Mon) so you can go by car to San Miguel de Allende.

Things to do in Mexico City

Historic Sites Museums Neighborhoods

Side Trip

Zona Arqueologica Teotihuacan
Find places to stay Aug 28 — Sep 2:
Highlights from your plan
Museo Nacional de Antropologia ©
Museo Nacional de Antropologia
Zona Arqueologica Teotihuacan ©
Zona Arqueologica Teotihuacan
Palacio de Bellas Artes ©
Palacio de Bellas Artes

5
nights
San Miguel de Allende, Mexico

San Miguel de Allende ©
A relatively small town in central Mexico, relaxed San Miguel de Allede offers an ideal setting for visitors in search of a bit of history and a great deal of photogenic architecture.
Satisfy your inner culture vulture at Parroquia de San Miguel Arcangel and El Jardin. Historic Center of Santiago de Queretaro and Temple of the Jesuit Order (Templo de la Compania de Jesus) will appeal to history buffs. Change things up with these side-trips from San Miguel de Allende: Santuario de Jesus Nazareno (in Atotonilco), Queretaro City (Museo de Arte Sacro Queretaro & Museo Regional) and Guanajuato (Museo del Pueblo de Guanajuato, Alhondiga de Granaditas, & more). The adventure continues: see the interesting displays at La Esquina Mexican Toy Museum, get engrossed in the history at Museo Histórico Casa de Allende, tour the pleasant surroundings at El Charco del Ingenio, and pause for some serene contemplation at Iglesia San Rafael o Santa Escuela de Cristo.

You can plan San Miguel de Allende trip in no time by asking Inspirock to help create your itinerary.

Traveling by car from Mexico City to San Miguel de Allende takes 3.5 hours. Alternatively, you can take a shuttle; or take a bus. Traveling from Mexico City in September, you will find days in San Miguel de Allende are a bit warmer (31°C), and nights are about the same (15°C). Finish your sightseeing early on the 7th (Sat) to allow enough time to drive to Puebla.

Things to do in San Miguel de Allende

Museums Historic Sites Shopping

Side Trips

Guanajuato, Queretaro City, Santuario de Jesus Nazareno
Find places to stay Sep 2 — 7:
Highlights from your plan
Museo La Esquina ©
Museo La Esquina
Parroquia de San Miguel Arcangel ©
Parroquia de San Miguel Arcangel
El Jardin ©
El Jardin

5
nights
Puebla, Mexico

Puebla ©
Recognized as a World Heritage Site thanks to its photogenic colonial buildings, Puebla remains one of Mexico's top destinations for architecture enthusiasts.
Deepen your sense of the past at sights like Church of Santa Maria Tonantzintla and Catedral Basilica de Puebla. Do some cultural sightseeing at Rosary Chapel (Capilla del Rosario) and Zona Arqueológica de Cholula. Change things up with these side-trips from Puebla: San Pedro Cholula (Santuario de la Virgen de los Remedios & Parroquia de San Andres Cholula), Church of Santa Maria (in Santa Maria Tonantzintla) and Tlaxcala (Basilica de Nuestra Senora de Ocotlan & Murals of the Government Palace). There's still lots to do: examine the collection at Amparo Museum (Museo Amparo), contemplate in the serene atmosphere at Ex-Convento de San Gabriel, wander the streets of Zocalo, and explore the world behind art at Museo de Artes Populares.

To see other places to visit, maps, ratings, and other tourist information, read our Puebla vacation tool .

Drive from San Miguel de Allende to Puebla in 4.5 hours. Alternatively, you can take a bus; or do a combination of bus, taxi, and flight. While traveling from San Miguel de Allende, expect a bit cooler days and about the same nights in Puebla, ranging from highs of 27°C to lows of 14°C. Wrap up your sightseeing on the 12th (Thu) early enough to travel to Chichen Itza.

Things to do in Puebla

Museums Historic Sites Neighborhoods

Side Trips

San Pedro Cholula, Tlaxcala, Kabah
Find places to stay Sep 7 — 12:
Highlights from your plan
Rosary Chapel (Capilla del Rosario) ©
Templo San Francisco Acatepec ©
Templo San Francisco Acatepec
Catedral Basilica de Puebla ©
Catedral Basilica de Puebla

1
night
Chichen Itza, Mexico

Chichen Itza ©
On the 13th (Fri), explore the ancient world of El Castillo, then make a trip to Chichen Itza, and then take in the dramatic natural features at Cenote Ik kil. Keep things going the next day: delve into the distant past at Nohoch Mul, wander the streets of Felipe Carrillo Puerto, explore the ancient world of Dzibichaltun, then explore the ancient world of La Iglesia, then explore the ancient world of Las Monjas, and finally explore the ancient world of Venus Platform.

To find ratings, reviews, photos, and more tourist information, use the Chichen Itza day trip planning app .

Traveling by combination of bus and flight from Puebla to Chichen Itza takes 7 hours. Alternatively, you can do a combination of flight and bus; or drive. Traveling from Puebla to Chichen Itza, you'll lose 1 hour due to the time zone difference. When traveling from Puebla in September, plan for somewhat warmer days in Chichen Itza, with highs around 38°C, while nights are much warmer with lows around 30°C. Finish your sightseeing early on the 14th (Sat) to allow enough time to drive to Tulum.

Things to do in Chichen Itza

Historic Sites Nature Parks

Side Trip

Yucatan Peninsula
Find places to stay Sep 12 — 14:
Highlights from your plan
Chichen Itza ©
Chichen Itza
Temple of the Bearded Man ©
Temple of the Bearded Man
The Ossuary ©
The Ossuary

5
nights
Tulum, Mexico

Tulum ©
The only Mayan site built to overlook the ocean, Tulum remains a coastal paradise preserving the last vestiges of a pre-Hispanic civilization.
Get some cultural insight at Ruins of Tulum and Ek Balam. Get some historical perspective at Cobá Zona Arqueológica Cobá and Las Pinturas. Step out of Tulum to go to Playa del Carmen and see Xcaret Park, which is approximately 56 minutes away. Plan for a day of cool, family-friendly fun on the 18th (Wed) at Xel-Ha. And it doesn't end there: stroll through Playa Paraiso, take an in-depth tour of Museo de la Prehistoria Parque Dos Ojos, kick back and relax at Akumal Beach, and explore the fascinating underground world of Grand Cenote.

For where to stay, traveler tips, photos, and tourist information, read Tulum planning tool .

You can drive from Chichen Itza to Tulum in 2 hours. Other options are to take a shuttle; or take a bus. Traveling from Chichen Itza in September, things will get little chillier in Tulum: highs are around 34°C and lows about 26°C. Wrap up your sightseeing on the 19th (Thu) to allow time to travel to Panama City.

Things to do in Tulum

Outdoors Theme Parks Parks

Side Trips

Xcaret Park, Xel-Ha, Akumal Beach, Ek Balam, Cobá Zona Arqueológica Cobá
Find places to stay Sep 14 — 19:
Highlights from your plan
Tulum Archaeological Site ©
Tulum Archaeological Site
Cobá Zona Arqueológica Cobá ©
Cobá Zona Arqueológica Cobá
Ek Balam
Ek Balam

3
nights
Panama City, Panama

Panama City ©
Arguably the most modern of Central American cities, Panama City boasts a shimmering skyline of glass skyscrapers.
Get a sense of the local culture at Casco Viejo and Fort San Lorenzo. Gatun Locks and Panama La Vieja will appeal to history buffs. Step out of Panama City to go to Portobelo and see Museo de La Real Aduana de Portobelo, which is approximately 1h 50 min away. The adventure continues: don't miss a visit to Panama Canal, stroll through Isla Santa Catalina, take in the architecture and atmosphere at Iglesia de San Francisco de Asis, and take an in-depth tour of Museo del Canal Interoceanico de Panama.

To see more things to do, maps, and other tourist information, refer to the Panama City day trip planner.

Traveling by combination of bus and flight from Tulum to Panama City takes 7 hours. Alternatively, you can drive. In September, plan for daily highs up to 36°C, and evening lows to 28°C. Finish your sightseeing early on the 23rd (Mon) so you can travel to Bogota.

Things to do in Panama City

Historic Sites Neighborhoods Museums

Side Trips

Colon, Isla Santa Catalina, Museo de La Real Aduana de Portobelo
Find places to stay Sep 19 — 23:
Highlights from your plan
Casco Viejo ©
Casco Viejo
Museo del Canal Interoceanico de Panama ©
Museo de La Real Aduana de Portobelo ©

5
nights
Bogota, Colombia

Bogota ©
Colombia's heart and soul, Bogota has earned the nickname "Athens of South America" thanks to its abundance of universities, libraries, and lower-level schools.
Get some historical perspective at Catedral de Sal and Our Lady of Mount Carmel Sanctuary. Do some cultural sightseeing at Gold Museum (Museo del Oro) and National Museum of Colombia. Explore the numerous day-trip ideas around Bogota: Zipaquira (Esensal & Catedral Diocesana), Laguna de Guatavita (in Tierra Negra) and Museo Aeroespacial Colombiano (in Tocancipa). There's lots more to do: explore the world behind art at Museo Botero del Banco de la Republica, indulge in some culinary diversions at a local gastronomic tour, take in the exciting artwork at DIBS by Culture Shock Colombia, and steep yourself in history at Bolivar plaza.

For maps, where to stay, photos, and more tourist information, read Bogota tour planner .

You can do a combination of taxi and flight from Panama City to Bogota in 2.5 hours. Other options are to do a combination of shuttle and flight; or do a combination of car, ferry, and bus. Traveling from Panama City in September, things will get cooler in Bogota: highs are around 22°C and lows about 9°C. Wrap up your sightseeing on the 28th (Sat) to allow time to travel back home.

Things to do in Bogota

Museums Nature Parks

Side Trips

Zipaquira, Museo Aeroespacial Colombiano, Laguna de Guatavita
Find places to stay Sep 23 — 28:
Highlights from your plan
Gold Museum (Museo del Oro) ©
Gold Museum (Museo del Oro)
Catedral de Sal ©
Catedral de Sal

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