21 days in Argentina, Chile & Peru Itinerary

21 days in Argentina, Chile & Peru Itinerary

Created using Inspirock South America trip itinerary builder
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Buenos Aires, Argentina
— 3 nights
Mendoza, Argentina
— 3 nights
Santiago, Chile
— 3 nights
Valparaiso, Chile
— 4 nights
Cusco, Peru
— 4 nights
Machu Picchu, Peru
— 1 night


Buenos Aires, Argentina — 3 nights

Cultural capital of South America, Buenos Aires remains one of the largest cities on the continent, serving as a point of departure for exploring the rest of the country.
Do some cultural sightseeing at Puerto Madero and Museo de Arte Latinoamericano de Buenos Aires. Museum-lovers will appreciate Museo Nacional de Bellas Artes and El Zanjon de Granados. The adventure continues: stroll the grounds of Cemiterio de Recoleta, listen to music at Centro Cultural Borges, contemplate the long history of Museo Nacional De Arte Decorativo, and get a sense of history and politics at Casa Rosada.

To find maps, ratings, traveler tips, and more tourist information, use the Buenos Aires trip itinerary maker website.

Sao Paulo, Brazil to Buenos Aires is an approximately 5.5-hour flight. You can also drive; or do a combination of bus and ferry. Expect slightly colder temperatures when traveling from Sao Paulo in May; daily highs in Buenos Aires reach 20°C and lows reach 14°C. Wrap up your sightseeing on the 14th (Fri) early enough to fly to Mendoza.
Museums · Historic Sites · Shopping · Neighborhoods
Find places to stay May 10 — 14:

Mendoza, Argentina — 3 nights

Famed for its neat vineyards and thriving wine production, Mendoza remains the place to visit for a pleasant combination of relaxation and recreation.
Your cultural itinerary includes sights like Bodega Cruzat. Bubbles Experience and Casa El Enemigo. Go for a jaunt from Mendoza to Tupungato to see Valle de Uco about 1h 25 min away. There's lots more to do: learn about winemaking at Bodega Roberto Bonfanti, brush up on your knowledge of spirits at Casa Tapaus Destilados, take an in-depth tour of Museo Fundacional, and stroll around Parque General San Martin.

To find photos, ratings, where to stay, and other tourist information, read our Mendoza online trip builder.

Fly from Buenos Aires to Mendoza in 3.5 hours. Alternatively, you can drive; or take a bus. Traveling from Buenos Aires in May, plan for a bit cooler nights in Mendoza, with lows around 9°C. Finish up your sightseeing early on the 17th (Mon) so you can catch the flight to Santiago.
Wineries · Parks · Museums · Nature
Side Trips
Find places to stay May 14 — 17:

Santiago, Chile — 3 nights

Santiago tourism thrives largely thanks to the city's big selection of cultural and entertainment options, including museums, theaters, restaurants, bars, and giant malls.
Satisfy your inner culture vulture at Museo Chileno de Arte Precolombino and Museo de la Memoria y los Derechos Humanos. Let the collections at La Chascona and Chilean National Museum of Fine Arts capture your imagination. Next up on the itinerary: get great views at San Cristóbal Hill, stroll around Cerro Santa Lucia, get a new perspective on nature at National Museum of Natural History, and visit Barrio Bellavista.

To see traveler tips, ratings, where to stay, and more tourist information, go to the Santiago route builder.

Traveling by flight from Mendoza to Santiago takes 4.5 hours. Alternatively, you can drive; or take a bus. The time zone difference when traveling from Mendoza to Santiago is minus 1 hour. Wrap up your sightseeing on the 20th (Thu) to allow time to drive to Valparaiso.
Museums · Parks · Neighborhoods · Nature
Find places to stay May 17 — 20:

Valparaiso, Chile — 4 nights

Navigating through a maze of colorful streets winding up and down steep hills remains an integral part of any Valparaiso tour.
Get some cultural insight at Casa de Isla Negra and Corporacion Museo de Arqueologia e Historia Francisco Fonck. Take a break from the city and head to Playa de Zapallar and Reñaca. You'll find plenty of places to visit near Valparaiso: Playa El Pejerrey (in Algarrobo), La Rambla (in Zapallar) and Matetic Vineyards (in Lagunillas). The adventure continues: examine the collection at La Sebastiana, make a trip to Edificio Luis Cousino, and stroll through Rocas de Santo Domingo.

To see maps, photos, reviews, and other tourist information, refer to the Valparaiso trip itinerary planner.

You can drive from Santiago to Valparaiso in 1.5 hours. Another option is to take a bus. In May, daily temperatures in Valparaiso can reach 19°C, while at night they dip to 11°C. Finish up your sightseeing early on the 24th (Mon) so you can catch the flight to Cusco.
Beaches · Parks · Outdoors · Museums
Side Trips
Find places to stay May 20 — 24:

Cusco, Peru — 4 nights

Capital of the Inca Empire for three centuries, World Heritage-listed Cusco is now a major tourist destination, drawing nearly 2 million annual tourists with its well-preserved colonial architecture and proximity to Machu Picchu.
Sacsayhuaman and San Blas are good opportunities to explore the local culture. Take a break from the city and head to Salinas de Maras and exploor. Step out of Cusco with an excursion to Moray in Maras--about 1h 20 min away. Next up on the itinerary: explore the world behind art at Museo de Arte Precolombino, explore the ancient world of Qorikancha, take an in-depth tour of Museo de Vida Monastica - Monasterio de Santa Catalina del Cusco, and admire the landmark architecture of Centro Historico De Cusco.

To see other places to visit, traveler tips, photos, and more tourist information, go to the Cusco online vacation planner.

Fly from Valparaiso to Cusco in 6.5 hours. Alternatively, you can drive; or take a bus. Due to the time zone difference, you'll gain 1 hour traveling from Valparaiso to Cusco. Expect somewhat warmer weather when traveling from Valparaiso in May: highs in Cusco hover around 24°C, while lows dip to 4°C. Wrap up your sightseeing on the 28th (Fri) early enough to drive to Machu Picchu.
Historic Sites · Museums · Parks · Nature
Side Trip
Find places to stay May 24 — 28:

Machu Picchu, Peru — 1 night

A symbol of the Incan civilization, the abandoned city of Machu Picchu represents a must-see on a Peru vacation.
Start off your visit on the 29th (Sat): steep yourself in history at Santuario Historico de Machu Picchu, then pause for some serene contemplation at Iglesia Virgen Del Carmen, and then look for gifts at Mapi Art.

To plan Machu Picchu vacation without wasting time, ask Inspirock to design an itinerary.

Getting from Cusco to Machu Picchu by car takes about 4.5 hours. Other options: do a combination of bus and train; or take a train. Finish up your sightseeing early on the 29th (Sat) so you can catch the flight back home.
Historic Sites · Shopping
Find places to stay May 28 — 29:

Argentina travel guide

Landmarks · Bodies of Water · Specialty Museums
Land of Contrasts
Home to the highest and lowest points in South America, diverse Argentina enthralls visitors with its contrasting landscapes and rich cultural heritage. A tour of Argentina reveals a sprawling land of fiercely proud and hardworking gauchos, the legendary cowboys of South America's pampas. A vacation in Argentina also leads you to giant urban centers, filled with modern tourist attractions that include fine restaurants, award-winning museums, and renowned public parks, gardens, and zoos. Away from big cities, Argentina sightseeing combines visits to mighty waterfalls situated inside World Heritage-listed national parks in the north of the country, with excursions to icy glaciers in the south.

Chile travel guide

Landmarks · Parks · Specialty Museums
Land of Poets
Squeezed between the Andes and the Pacific Ocean, geographically diverse Chile is a long, thin stretch of land encompassing some of the world's driest deserts in the north, and some of its largest glacial fields in the south. Though most Chile holidays include some form of adventure in the vast wilderness areas, the country also contains charming cities providing plenty of urban things to do and see. Many tours of Chile include at least a brief visit to the country's lush wine regions, where backyard vineyards compete with sprawling estates producing some of the world's most respected whites and reds.

Peru travel guide

Historic Sites · Parks · Landmarks
Land of the Incas
In a country renowned for its pre-Columbian archeological sites, no Peru vacation would be complete without an adrenaline-inducing hike to Machu Picchu, World Heritage-listed symbol of the once-mighty Incan Empire. Aside from visiting these spectacular ruins set against the backdrop of photogenic mountain peaks, most holidays in Peru also include an exploration of the country's pretty cities, boasting well-preserved colonial architecture and a slew of modern buildings housing fine museums, galleries, shops, and restaurants. Ideal for active vacationers, Peru trips are also tailor-made for gourmands, as the country's eclectic cuisine blends tasty influences from Africa, Asia, and Europe.